Don Karnage (voiced by Jim Cummings) is a wolf pirate with a notched ear who is usually dressed in a blue tailcoat, trousers, and black boots, wielding a cutlass. He has a mottled accent that has been described as a mix of Spanish, Italian, and French. Jim Cummings has admitted that he drew some influence from the Desi Arnaz role of Ricky Ricardo (from I Love Lucy). Karnage is quite self-absorbed and spends a good bit of time speaking highly of himself. He is easily the most competent of the air pirates, although that's not much of an achievement, since most of the others tend to be bumblers. He also serves as the captain of the air pirates.
Mad Dog (voiced by Charlie Adler) seems to resemble a weasel almost as much as a canine, and he's usually found wearing cloth headgear, flight goggles, a sleeveless blue jerkin, and spiked bracers. He also has a whisker mustache in Fu Manchu style. Mad Dog has a whiny, nasally voice and is the smarter of the two main henchmen... which, again, is not saying much. He tends to be a bit lazy, loves to take credit for anything good, and loves to shift blame for anything bad.
Dumptruck (voiced by Chuck McCann) resembles a mastiff. He's fairly large and barrel-chested. He wears a top hat, blue kerchief, an auburn and white jacket, and an ammo belt across his chest. He doesn't seem very bright. Dumptruck speaks with a Swedish accent.
Gibber (voiced by Chuck McCann) is another pirate that is often featured. He's rather short, dressed in a brown flightcap, a patched yellow jacket, and a reddish orange sweater. He only talks by whispering or mumbling into someone's ear so that no one else can really understand what he's saying.
Hacksaw (voiced by Charlie Adler) is a large yellow-furred dog with a tufted goatee and often a crazy enthusiastic gleam in his eyes. He wears a sleeveless blue vest, armbands laced with dynamite, moss green trousers, and his ears are tucked into a jeweled ring above his head. He's known to cause great disaster through his enthusiasm to do something useful for the pirates, usually because he's not thinking about the consequences.
Ratchet (voiced by Rob Paulsen) is a thin wolf-like pirate that wears a blue cap, a green scarf, a yellow shirt, blue overalls, and black fingerless gloves. Described by Don Karnage as their "mechanical genius," he seems to handle any repairs and mechanics for the pirates.
Jock is a Scottish terrier that wears a red toupeé, blue sunglasses, and a red-and-white striped shirt. He is Don Karnage's head pilot of the Iron Vulture. Karnage often mistakenly calls him "Scotty," though Jock eventually tells him otherwise. Jock is one of the few Air Pirates who is not seen doing any harm to other people, possibly making him a positive person. Most of the time, Jock is seen sleeping.
Will is Don Karnage's second mate, seen very briefly in the episode "In Search of Ancient Blunders" as part of a single gag: Don Karnage ordered his crew to "Fire at will!". Ever obedient, they began shooting at Will as he ran past Karnage, instead of shooting at the Sea Duck which was what Karnage meant.
Sadie is a short, fat, brown pirate who has a grey mustache and wears a Viking helmet.